Siladitya Ray Chaudhuri is currently a Senior Scientist within Discovery Sciences at Janssen (Pharmaceutical Companies of Johnson & Johnson). Sil’s core area of expertise is in mechanistic physiologically-based modeling and simulation concepts. His primary work focuses on predicting clinical exposure and first-in-human dose for simple to complex formulations. Sil has spent over 15 years in this area, with special emphasis on non-oral routes of administration. Before Janssen, Sil was a part of Simulations Plus, where he helped develop first-in-class mechanistic PBPK modeling and simulation tools for ophthalmic, nasal-pulmonary and transdermal administration. These tools have since been commercialized and used widely by the industry. Some of these tools have also been endorsed by the FDA and funded for further development. Sil has also been a part of Translational Pharmacokinetics at Allergan where he helped with modeling and simulation and DMPK activities across multiple ophthalmic and transdermal projects at various stages of pharmaceutical development.
Sil has been very active within AAPS for several years having served as Chair for the Ocular Drug Delivery & Disposition Focus Group (ODDFG). He is currently the Secretary of the Formulation Design & Development Section of AAPS. Sil has published multiple peer-reviewed articles, has been invited to write white papers and cover articles and to speak at national and international conferences as well as regulatory authorities (US Food & Drug Administration). He received his Bachelor of Science in Chemistry from St. Xavier’s College, Calcutta, India (1997) and Bachelor of Technology in Chemical Engineering from the University of Calcutta, Calcutta, India (2000). Sil received his MS in Chemical Engineering (2003) and Ph. D. in Chemical Engineering (2007) from the University of Cincinnati, Cincinnati, OH, where he worked on mathematical models and computer simulations of the dermal absorption of volatile formulations under the supervision of Prof. Gerald B. Kasting.